2249864-11-5
Chemical Structure
LM9
- CAS No.: 2249864-11-5
- Formula:C24H27N5O5S
- Molecular Weight:497.57
IUPAC Name: N-(4-(4-hydroxy-3-methoxyphenyl)thiazol-2-yl)-3-(4-(3-nitrobenzyl)piperazin-1-yl)propanamide
InChIKey: UBQIVARJJWYNRS-UHFFFAOYSA-N
SMILES: O=C(CCN1CCN(CC1)CC2=CC([N+]([O-])=O)=CC=C2)NC3=NC(C4=CC(OC)=C(O)C=C4)=CS3
Biological Activity: LM9 is a potent, orally active MyD88 inhibitor. LM9 blocks TLR4/MyD88 binding, MyD88 homodimer formation, and TLR4/MyD88/NF-κB signaling pathway activation. LM9 prevents atherosclerosis by regulating inflammatory responses and oxidative stress in macrophages. LM9 efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy. LM9 can be used for fibrosis and atherosclerosis research[1][2].
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LM9 | LM9 is a potent, orally active MyD88 inhibitor. LM9 blocks TLR4/MyD88 binding, MyD88 homodimer formation, and TLR4/MyD88/NF-κB signaling pathway activation. LM9 prevents atherosclerosis by regulating inflammatory responses and oxidative stress in macrophages. LM9 efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy. LM9 can be used for fibrosis and atherosclerosis research. | |||||||||||||||||||||
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References
- [1]. Zheng XY, et al. Compound LM9, a novel MyD88 inhibitor, efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy. Acta Pharmacol Sin. 2020;41(8):1093-1101. [Content Brief]
- [2]. Chen T, et al. A novel MyD88 inhibitor LM9 prevents atherosclerosis by regulating inflammatory responses and oxidative stress in macrophages. Toxicol Appl Pharmacol. 2019;370:44-55. [Content Brief]
