2250084-67-2
2250084-67-2
Chemical Structure
PLK1/BRD4-IN-6
- CAS No.: 2250084-67-2
- Formula:C31H43N7O3
- Molecular Weight:561.72
InChIKey: HTPNGOWITIWAHM-HXUWFJFHSA-N
SMILES: O=C(NC1CCN(C)CC1)C2=CC=C(NC(N=C3N(C4CCCC4)[C@@H]5C)=NC=C3N(C)C5=O)C(OC6CCCC6)=C2
Biological Activity: PLK1/BRD4-IN-6 is a PLK1 inhibitor that inhibits PLK1 kinase activity and acetyl-lysine binding of BRD4-BD1 and BRDT-BD1 (IC50 = 0.0099 µM, 2.579 µM, and 8.468 µM, respectively), and shows higher selectivity for PLK1 than BRD4 in biochemical assays. PLK1/BRD4-IN-6 can be used for research on acute myeloid leukemia[1].
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PLK1/BRD4-IN-6 | PLK1/BRD4-IN-6 is a PLK1 inhibitor that inhibits PLK1 kinase activity and acetyl-lysine binding of BRD4-BD1 and BRDT-BD1 (IC50 = 0.0099 µM, 2.579 µM, and 8.468 µM, respectively), and shows higher selectivity for PLK1 than BRD4 in biochemical assays. PLK1/BRD4-IN-6 can be used for research on acute myeloid leukemia. | |||||||||||||||||||||
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