2254567-00-3
2254567-00-3
Chemical Structure
BWC0977
- CAS No.: 2254567-00-3
- Formula:C22H21FN6O5
- Molecular Weight:468.44
InChIKey: MKICNOUBIXXGPQ-ZDUSSCGKSA-N
SMILES: O=C1N(C)C2=C(CCNC[C@H]3CN(C4=CN=C(OCC(N5)=O)C5=N4)C(O3)=O)C(F)=CC=C2C=C1
Biological Activity: BWC0977 acts as an inhibitor of bacterial Topoisomerase. BWC0977 stabilizes single-strand DNA breaks, inhibits DNA supercoiling and decatenation activities, binds to GyrA and ParC residues, and activates the SOS response. BWC0977 can be used in research related to multidrug-resistant bacterial infections[1][2][3][4].
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BWC0977 | BWC0977 acts as an inhibitor of bacterial Topoisomerase. BWC0977 stabilizes single-strand DNA breaks, inhibits DNA supercoiling and decatenation activities, binds to GyrA and ParC residues, and activates the SOS response. BWC0977 can be used in research related to multidrug-resistant bacterial infections. | |||||||||||||||||||||
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References
- [1]. Fernandes GFS, et al. Antibacterial drug discovery: challenges and preclinical promises from synthetic small molecules. Chemical Society reviews. 2026 Jul 20;55(14):7853-7932.
- [2]. Hameed S, et al.BWC0977, a Novel Dual Target Topoisomerase Inhibitor: Antimicrobial Potency, Spectrum, and Mechanism of Action[C]. 29th European Congress on Clinical Microbiology and Infectious Diseases, Amsterdam, Netherlands P. 2019, 1844.
- [3]. Hameed P S, et al. BWC0977, a broad-spectrum antibacterial clinical candidate to treat multidrug resistant infections. Nature communications. 2024 Sep 18;15(1):8202. [Content Brief]
- [4]. Nandishaiah R, et al. Structural interactions of BWC0977 with Klebsiella pneumoniae topoisomerase IV and biochemical basis of its broad-spectrum activity. Communications biology. 2025 Nov 25;8(1):1666.
