22737-97-9
Chemical Structure
9-cis Retinol
- CAS No.: 22737-97-9
- Formula:C20H30O
- Molecular Weight:286.45
InChIKey: FPIPGXGPPPQFEQ-MKOSUFFBSA-N
SMILES: OC/C=C(C)/C=C/C=C(C)\C=C\C1=C(C)CCCC1(C)C
Biological Activity: 9-cis Retinol is an upstream precursor of 9-cis-Retinal (HY-W009310) and 9-cis-Retinoic acid (HY-15128). 9-cis Retinol serves as a reaction substrate for cRDH, ARAT and LRAT, participates in cellular uptake and isomerization processes, and can be oxidized to form 9-cis-Retinal in the biosynthetic pathway. 9-cis Retinol inhibits the activity of 9-cis retinaldehyde dehydrogenase, thereby blocking the biosynthesis of 9-cis-Retinoic acid. 9-cis Retinol is applicable for metabolism-related research[1][2].
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9-cis Retinol | 97.0% | 9-cis Retinol is an upstream precursor of 9-cis-Retinal (HY-W009310) and 9-cis-Retinoic acid (HY-15128). 9-cis Retinol serves as a reaction substrate for cRDH, ARAT and LRAT, participates in cellular uptake and isomerization processes, and can be oxidized to form 9-cis-Retinal in the biosynthetic pathway. 9-cis Retinol inhibits the activity of 9-cis retinaldehyde dehydrogenase, thereby blocking the biosynthesis of 9-cis-Retinoic acid. 9-cis Retinol is applicable for metabolism-related research. | ||||||||||||||||||||
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9-cis-Retinol-d5 | 9-cis-Retinol-d5 is the deuterated-labeled 9-cis Retinol (HY-W587806). 9-cis Retinol is an upstream precursor of 9-cis-Retinal (HY-W009310) and 9-cis-Retinoic acid (HY-15128). 9-cis Retinol serves as a reaction substrate for cRDH, ARAT and LRAT, participates in cellular uptake and isomerization processes, and can be oxidized to form 9-cis-Retinal in the biosynthetic pathway. 9-cis Retinol inhibits the activity of 9-cis retinaldehyde dehydrogenase, thereby blocking the biosynthesis of 9-cis-Retinoic acid. 9-cis Retinol is applicable for metabolism-related research. | |||||||||||||||||||||
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References
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[1]. Paik J, et al. 9-cis-Retinoids: Biosynthesis of 9-cis-Retinoic Acid. Biochemistry, 2000, 39(27): 8073-8084.
- [2]. Romert A, et al. The identification of a 9-cis retinol dehydrogenase in the mouse embryo reveals a pathway for synthesis of 9-cis retinoic acid. Proceedings of the National Academy of Sciences of the United States of America. 1998 Apr 14;95(8):4404-9.
