2294965-95-8
Chemical Structure
HPK1-IN-16
- CAS No.: 2294965-95-8
- Formula:C28H27FN4O
- Molecular Weight:454.54
IUPAC Name: 5-(2-fluoro-6-methyl-4-((methylamino)methyl)phenyl)-3-(4-(tetrahydro-2H-pyran-4-yl)phenyl)-1H-indazole-6-carbonitrile
InChIKey: FLVHPYFASVFXNT-UHFFFAOYSA-N
SMILES: N#CC1=C(C2=C(C=C(CNC)C=C2C)F)C=C3C(C4=CC=C(C5CCOCC5)C=C4)=NNC3=C1
Biological Activity: HPK1-IN-16 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-16 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2019051199A1, compound 39)[1].
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HPK1-IN-16 | HPK1-IN-16 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-16 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2019051199A1, compound 39). | |||||||||||||||||||||
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Keywords
