2304-75-8
2304-75-8
Chemical Structure
DL-threo-Dihydrosphingosine
- CAS No.: 2304-75-8
- Formula:C18H39NO2
- Molecular Weight:301.51
InChIKey: OTKJDMGTUTTYMP-ROUUACIJSA-N
SMILES: CCCCCCCCCCCCCCC[C@H](O)[C@@H](N)CO
Biological Activity: DL-threo-Dihydrosphingosine is a extracellular signal-regulated kinase(ERK) signalling cassette inhibitor and is effective against both growth factor- and G-protein-dependent activation of ERK. DL-threo-Dihydrosphingosine inhibits smooth muscle cell proliferation and can be used for study of asthma[1][2].
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DL-threo-Dihydrosphingosine | DL-threo-Dihydrosphingosine is a extracellular signal-regulated kinase(ERK) signalling cassette inhibitor and is effective against both growth factor- and G-protein-dependent activation of ERK. DL-threo-Dihydrosphingosine inhibits smooth muscle cell proliferation and can be used for study of asthma. | |||||||||||||||||||||
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References
- [1]. Tolan D, et al. The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle. Br J Pharmacol. 1996;119(2):185-186. [Content Brief]
- [2]. Yoshida K, et al. ELOVL6 deficiency aggravates allergic airway inflammation through the ceramide-S1P pathway in mice. J Allergy Clin Immunol. 2023;151(4):1067-1080.e9. [Content Brief]
