2345648-37-3
2345648-37-3
Chemical Structure
IKKβ-IN-2
- CAS No.: 2345648-37-3
- Formula:C19H14BrFN6O
- Molecular Weight:441.26
IUPAC Name: 1-(3-bromo-4-fluorophenyl)-3-(3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)urea
InChIKey: WXERUDVRQZONGM-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(F)C(Br)=C1)NC=2C=CC=3N=CC(=NC3C2)C=4C=NN(C4)C
Biological Activity: IKKβ-IN-2 is an orally effective IκB kinase β (IKKβ) inhibitor. IKKβ-IN-2 inhibits the activity of IKKβ, thereby blocking TNFα-induced downstream NF-κB pathway activation and transcription, thus exerting inhibitory effects on inflammation and tumor growth. IKKβ-IN-2 can be used for research on colon cancer and pancreatic cancer[1].
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IKKβ-IN-2 | IKKβ-IN-2 is an orally effective IκB kinase β (IKKβ) inhibitor. IKKβ-IN-2 inhibits the activity of IKKβ, thereby blocking TNFα-induced downstream NF-κB pathway activation and transcription, thus exerting inhibitory effects on inflammation and tumor growth. IKKβ-IN-2 can be used for research on colon cancer and pancreatic cancer. | |||||||||||||||||||||
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