23465-76-1
23465-76-1
Chemical Structure
Caroverine
- CAS No.: 23465-76-1
- Formula:C22H27N3O2
- Molecular Weight:365.47
IUPAC Name: 1-(2-(diethylamino)ethyl)-3-(4-methoxybenzyl)quinoxalin-2(1H)-one
InChIKey: MSPRUJDUTKRMLM-UHFFFAOYSA-N
SMILES: O=C1C(CC2=CC=C(C=C2)OC)=NC3=C(N1CCN(CC)CC)C=CC=C3
Biological Activity: Caroverine is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. Caroverine is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action. Caroverine can be used for the research of inner ear tinnitus[1][2][3].
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Caroverine | Caroverine is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. Caroverine is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action. Caroverine can be used for the research of inner ear tinnitus. | |||||||||||||||||||||
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References
- [1]. Chen Z, et, al. Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs. Audiol Neurootol. Jan-Feb 2003;8(1):49-56. [Content Brief]
- [2]. Denk DM, et, al. Caroverine in tinnitus treatment. A placebo-controlled blind study. Acta Otolaryngol. 1997 Nov;117(6):825-30. [Content Brief]
- [3]. Ishida Y, et, al. Vasorelaxant action of caroverine fumarate (a quinoxaline derivative), a calcium-blocking agent. Br J Pharmacol. 1980;71(1):343-8. [Content Brief]
Keywords
