2378640-25-4
Chemical Structure
Perforin-IN-1
- CAS No.: 2378640-25-4
- Formula:C24H18F2N4O4S2
- Molecular Weight:528.55
IUPAC Name: 2,4-difluoro-N-(2-methoxy-5-(5-(6-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)thiophen-2-yl)pyridin-3-yl)benzenesulfonamide
InChIKey: ZYYGNLSPUWSHQW-UHFFFAOYSA-N
SMILES: FC1=CC(F)=CC=C1S(NC2=C(OC)N=CC(C3=CC=C(C4=CN=C(C(N(C)C5)=O)C5=C4)S3)=C2)(=O)=O
Biological Activity: Perforin-IN-1 is a perforin inhibitor that blocks perforin-mediated lysis of target cells by cytotoxic lymphocytes. Perforin-IN-1 achieves perforin inhibition in a mouse bone marrow transplantation model, protecting MHC-mismatched allogeneic bone marrow stem cell grafts from NK cell-mediated rejection. Perforin-IN-1 can be used for research on graft rejection[1].
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Perforin-IN-1 | Perforin-IN-1 is a perforin inhibitor that blocks perforin-mediated lysis of target cells by cytotoxic lymphocytes. Perforin-IN-1 achieves perforin inhibition in a mouse bone marrow transplantation model, protecting MHC-mismatched allogeneic bone marrow stem cell grafts from NK cell-mediated rejection. Perforin-IN-1 can be used for research on graft rejection. | |||||||||||||||||||||
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