2379527-49-6
2379527-49-6
Chemical Structure
EP300/CBP-IN-2
- CAS No.: 2379527-49-6
- Formula:C30H29D3F2N4O3
- Molecular Weight:537.62
InChIKey: SKDNDJWEBPQKCS-MGMIGZRFSA-N
SMILES: O=C1N(C2=CC(F)=C(C=C2)F)[C@@H](CCC1)C3=NC4=CC(C5=C(C)ON=C5C)=CC=C4N3[C@@H]6CC[C@H](CC6)OC([2H])([2H])[2H]
Biological Activity: EP300/CBP-IN-2 is a potent EP300/CBP inhibitor that has good activity in vivo. EP300/CBP-IN-2 can be used for the research of cancer[1].
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EP300/CBP-IN-2 | EP300/CBP-IN-2 is a potent EP300/CBP inhibitor that has good activity in vivo. EP300/CBP-IN-2 can be used for the research of cancer. | |||||||||||||||||||||
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Inobrodib | 99.95% | Inobrodib (CCS1477) is an orally active, potent, and selective inhibitor of the p300/CBP bromodomain. Inobrodib binds to p300 and CBP with Kd values of 1.3 and 1.7 nM, respectively, and with 170/130-fold selectivity compared with BRD4 with a Kd of 222 nM. CCS1477 inhibits cell proliferation in prostate cancer cell lines and decreases androgen receptor (AR)- and C-MYC-regulated gene expression. | ||||||||||||||||||||
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References
Keywords
