2379527-72-5
2379527-72-5
Chemical Structure
IDO1/TDO-IN-1
- CAS No.: 2379527-72-5
- Formula:C21H16O6
- Molecular Weight:364.35
IUPAC Name: (6,6-dimethyl-7,10,11-trioxo-6,7,10,11-tetrahydrophenanthro[1,2-b]furan-1-yl)methyl acetate
InChIKey: HBGFMECMJXIZLM-UHFFFAOYSA-N
SMILES: CC(OCC1=COC2=C1C(C(C3=C2C=CC4=C3C=CC(C4(C)C)=O)=O)=O)=O
Biological Activity: IDO1/TDO-IN-1 (30) is a potent dual IDO1 (uncompetitive, Ki of 0.23 μM) and TDO (competitive, Ki of 0.73 μM) inhibitor. IDO1/TDO-IN-1 (30) significantly promotes cell apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway[1].
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IDO1/TDO-IN-1 | IDO1/TDO-IN-1 (30) is a potent dual IDO1 (uncompetitive, Ki of 0.23 μM) and TDO (competitive, Ki of 0.73 μM) inhibitor. IDO1/TDO-IN-1 (30) significantly promotes cell apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway. | |||||||||||||||||||||
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References
Keywords
