2380001-43-2
Chemical Structure
Reverse transcriptase-IN-1
- CAS No.: 2380001-43-2
- Formula:C25H17N7O2
- Molecular Weight:447.45
IUPAC Name: (E)-4-((4-((4-(2-cyanovinyl)-2-methyl-6-nitrophenyl)amino)quinazolin-2-yl)amino)benzonitrile
InChIKey: MNZKGXAFXCQSCG-SNAWJCMRSA-N
SMILES: N#CC1=CC=C(NC2=NC(NC3=C([N+]([O-])=O)C=C(/C=C/C#N)C=C3C)=C4C=CC=CC4=N2)C=C1
Biological Activity: Reverse transcriptase-IN-1 (Compound 12z), a diarylbenzopyrimidine (DABP) analogue, is a potent, orally active HIV-1 nonnucleoside reverse transcriptase inhibitor. Reverse transcriptase-IN-1 has antiviral activity with EC50 values of 3.4 nM, 4.3 nM and 3.6 nM for HIV-1 IIIB, E138K and K103N mutants, respectively. Reverse transcriptase-IN-1 also has an IC50of 13.7 nM against HIV-1 reverse transcriptase enzyme[1].
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Reverse transcriptase-IN-1 | 98.99% | Reverse transcriptase-IN-1 (Compound 12z), a diarylbenzopyrimidine (DABP) analogue, is a potent, orally active HIV-1 nonnucleoside reverse transcriptase inhibitor. Reverse transcriptase-IN-1 has antiviral activity with EC50 values of 3.4 nM, 4.3 nM and 3.6 nM for HIV-1 IIIB, E138K and K103N mutants, respectively. Reverse transcriptase-IN-1 also has an IC50of 13.7 nM against HIV-1 reverse transcriptase enzyme. | ||||||||||||||||||||
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Keywords
