2387902-92-1
Chemical Structure
Anticancer agent 64
- CAS No.: 2387902-92-1
- Formula:C31H46N2O2S
- Molecular Weight:510.77
IUPAC Name: (1R,3aS,5aR,5bR,7aR,12aR,12bR,14aR,14bR)-10-amino-5a,5b,8,8,12a-pentamethyl-1-(prop-1-en-2-yl)-1,2,3,4,5,5a,5b,6,7,7a,8,12,12a,12b,13,14,14a,14b-octadecahydro-3aH-cyclopenta[7,8]chryseno[2,3-d]thiazole-3a-carboxylic acid
InChIKey: ODIHQYMUHPRVPR-NXEQSAOGSA-N
SMILES: OC([C@]12[C@@]([C@@H](CC2)C(C)=C)([H])[C@]3([H])[C@@](CC1)([C@]4([C@]([C@@]5([C@@](C(C)(C6=C(SC(N)=N6)C5)C)([H])CC4)C)([H])CC3)C)C)=O
Biological Activity: Anticancer agent 64 (compound 5m) shows cytotoxic activity in CCRF-CEM cells, with IC50 of 2.4 μM. Anticancer agent 64 shows good anticancer activity through apoptosis induction. Anticancer agent 64 induces caspase 3 and 7 activation and PARP cleavage. Anticancer agent 64 induces significant effect of mitochondria depolarization[1].
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Anticancer agent 64 | Anticancer agent 64 (compound 5m) shows cytotoxic activity in CCRF-CEM cells, with IC50 of 2.4 μM. Anticancer agent 64 shows good anticancer activity through apoptosis induction. Anticancer agent 64 induces caspase 3 and 7 activation and PARP cleavage. Anticancer agent 64 induces significant effect of mitochondria depolarization. | |||||||||||||||||||||
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Keywords
