23981-47-7
23981-47-7
Chemical Structure
α-Demethylnaproxen
- CAS No.: 23981-47-7
- Formula:C13H12O3
- Molecular Weight:216.24
IUPAC Name: 2-(6-methoxynaphthalen-2-yl)acetic acid
InChIKey: PHJFLPMVEFKEPL-UHFFFAOYSA-N
SMILES: O=C(O)CC1=CC=C2C=C(OC)C=CC2=C1
Biological Activity: α-Demethylnaproxen is the major metabolite of Nabumetone (HY-B0559), Nabumetone is an orally active COX-2 inhibitor with anti-inflammatory activity[1][2].
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α-Demethylnaproxen | 99.76% | α-Demethylnaproxen is the major metabolite of Nabumetone (HY-B0559), Nabumetone is an orally active COX-2 inhibitor with anti-inflammatory activity. | ||||||||||||||||||||
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α-Demethylnaproxen (Standard) | ≥98% | α-Demethylnaproxen (Standard) is the analytical standard of α-Demethylnaproxen (HY-W086896). This product is intended for research and analytical applications. α-Demethylnaproxen (Compound 6-MNA) is the major metabolite of Nabumetone (HY-B0559). Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor. | ||||||||||||||||||||
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Desmethyl Naproxen-d3 | 98.0% | Desmethyl Naproxen-d3 is deuterium labeled Desmethyl Naproxen. Desmethyl Naproxen is the metabolite of anti-inflammatory agent Naproxen. | ||||||||||||||||||||
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References
- [1]. Mikami E, et al. Simultaneous analysis of naproxen, nabumetone and its major metabolite 6-methoxy-2-naphthylacetic acid in pharmaceuticals and human urine by high-performance liquid chromatography. J Pharm Biomed Anal. 2000 Oct;23(5):917-25. [Content Brief]
- [2]. Vural F, et al. Cyclo-oxygenase 2 inhibitor, nabumetone, inhibits proliferation in chronic myeloid leukemia cell lines. Leuk Lymphoma. 2005 May;46(5):753-6. [Content Brief]
