2404652-24-8
Chemical Structure
MT-228
Synonym(s): BPN-0026709
- CAS No.: 2404652-24-8
- Formula:C19H19N3O3
- Molecular Weight:337.37
IUPAC Name: (S)-3a-hydroxy-1-(2-methoxypyridin-4-yl)-6,7-dimethyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
InChIKey: DUDYNUXUMAKUPK-LJQANCHMSA-N
SMILES: O=C1[C@@]2(O)C(N(C3=CC(OC)=NC=C3)CC2)=NC4=C1C=C(C)C(C)=C4
Biological Activity: MT-228 (BPN-0026709) is a selective and blood-brain barrier permeable non-muscle myosin II inhibitor. MT-228 markedly improves tolerability by selectively targeting NMIIB (KI = 1.5 μM) over CMII (KI = 17 μM), and the sequence of SmMll MD is 83.6% identical to that of NMllB. MT-228 shows long-lasting efficacy in animal models of stimulant use disorder[1].
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MT-228 | 99.9% | MT-228 (BPN-0026709) is a selective and blood-brain barrier permeable non-muscle myosin II inhibitor. MT-228 markedly improves tolerability by selectively targeting NMIIB (KI = 1.5 μM) over CMII (KI = 17 μM), and the sequence of SmMll MD is 83.6% identical to that of NMllB. MT-228 shows long-lasting efficacy in animal models of stimulant use disorder. | ||||||||||||||||||||
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Keywords
