2408134-22-3
Chemical Structure
RCD405
- CAS No.: 2408134-22-3
- Formula:C17H13Cl2F3N2O3S
- Molecular Weight:453.26
InChIKey: XMOXMJNCKFUEPL-UHFFFAOYSA-N
SMILES: OC1=C(O)C(Cl)=C(CCN(C(CSC2=CN=C(C(F)(F)F)C=C2)=O)C3)C3=C1Cl
Biological Activity: RCD405 is a bronchodilator. RCD405 exerts relaxant effects by acting directly on human airway smooth muscle (hASM) with an EC50 value of 12 μM for histamine-induced contractions and 45.71 μM for carbachol-induced contractions. RCD405 inhibits cholinergic and histaminergic tone and reduces electrically stimulated (EFS)-induced contractions. RCD405 is promising for research of asthma and chronic obstructive pulmonary disease (COPD)[1].
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RCD405 | RCD405 is a bronchodilator. RCD405 exerts relaxant effects by acting directly on human airway smooth muscle (hASM) with an EC50 value of 12 μM for histamine-induced contractions and 45.71 μM for carbachol-induced contractions. RCD405 inhibits cholinergic and histaminergic tone and reduces electrically stimulated (EFS)-induced contractions. RCD405 is promising for research of asthma and chronic obstructive pulmonary disease (COPD). | |||||||||||||||||||||
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Keywords
