2411874-83-2
2411874-83-2
Chemical Structure
LDC0496
- CAS No.: 2411874-83-2
- Formula:C32H35N5O3
- Molecular Weight:537.65
IUPAC Name: isopropyl 3-(3-acrylamido-4-methylphenyl)-2-(4-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate
InChIKey: MRQRFMNOQYTZTC-UHFFFAOYSA-N
SMILES: CC(C=CC(C1=C(NC2=NC=C(C=C21)C(OC(C)C)=O)C3=CC=C(C=C3)N4CCN(CC4)C)=C5)=C5NC(C=C)=O
Biological Activity: LDC0496 is a potent and selective EGFR inhibitor. LDC0496 possesses intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations, as well as selectivity over wild type EGFR and within the kinome[1].
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LDC0496 | LDC0496 is a potent and selective EGFR inhibitor. LDC0496 possesses intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations, as well as selectivity over wild type EGFR and within the kinome. | |||||||||||||||||||||
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References
Keywords
