2413974-53-3
2413974-53-3
Chemical Structure
Mt KARI-IN-4
- CAS No.: 2413974-53-3
- Formula:C13H8FN5O3S2
- Molecular Weight:365.36
IUPAC Name: 1-(4-fluorophenyl)-3-(5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl)thiourea
InChIKey: HDQHMZWYSJUDQT-UHFFFAOYSA-N
SMILES: O=[N+](C1=CC=C(O1)C2=NN=C(S2)NC(NC3=CC=C(C=C3)F)=S)[O-]
Biological Activity: Mt KARI-IN-4 (compound 5c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 5.48 μM. Mt KARI-IN-4 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 72 μg/mL)[1].
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Mt KARI-IN-4 | Mt KARI-IN-4 (compound 5c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 5.48 μM. Mt KARI-IN-4 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 72 μg/mL). | |||||||||||||||||||||
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References
Keywords
