2415989-91-0
2415989-91-0
Chemical Structure
SHP2-IN-23
- CAS No.: 2415989-91-0
- Formula:C24H23ClN8S
- Molecular Weight:491.01
InChIKey: BWQAQACZKDLJAW-OAQYLSRUSA-N
SMILES: N[C@H]1C2(CCN(C3=NC4=C(N=C(C=C4)SC5=CC=NC(N)=C5Cl)N=C3)CC2)CC6=NC=CC=C61
Biological Activity: SHP2-IN-23 (compound 30) is an orally active SHP2 inhibitor (IC50=38 nM) with excellent in vivo efficacy and pharmacokinetic profiles. SHP2-IN-23 inhibits ERK phosphorylation with IC50=5 nM[1].
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SHP2-IN-23 | SHP2-IN-23 (compound 30) is an orally active SHP2 inhibitor (IC50=38 nM) with excellent in vivo efficacy and pharmacokinetic profiles. SHP2-IN-23 inhibits ERK phosphorylation with IC50=5 nM. | |||||||||||||||||||||
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References
Keywords
