2417718-38-6
2417718-38-6
Chemical Structure
VT-105
- CAS No.: 2417718-38-6
- Formula:C24H18F3N3O
- Molecular Weight:421.41
InChIKey: FUKXXBXVSANFJK-HNNXBMFYSA-N
SMILES: C[C@@H](C1=CC=CC=N1)NC(C2=CC3=C(N=C2)C(C4=CC=C(C=C4)C(F)(F)F)=CC=C3)=O
Biological Activity: VT-105 is a TEAD inhibitor and VT104 (HY-134956) analog. VT-105 binds to the central hydrophobic pocket of the TEAD3 protein. VT-105 can be used in the research of NF2-deficient malignant mesothelioma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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VT-105 | 99.93% | VT-105 is a TEAD inhibitor and VT104 (HY-134956) analog. VT-105 binds to the central hydrophobic pocket of the TEAD3 protein. VT-105 can be used in the research of NF2-deficient malignant mesothelioma. | ||||||||||||||||||||
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References
- [1]. Tang TT, et al. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 Jun;20(6):986-998. [Content Brief]
- [2]. Hu L, et al. Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode. Elife. 2022 Nov 18;11:e80210. [Content Brief]
