2423969-43-9
2423969-43-9
Chemical Structure
KRL74
- CAS No.: 2423969-43-9
- Formula:C50H61ClN10O9
- Molecular Weight:981.53
InChIKey: LOGLGRQEQMNTCW-KBRUPHJGSA-N
SMILES: O=C([C@@H](NC([C@](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC1=O)C)=O)C(C)C)=O)CO)=O)=O)CC2=CNC3=CC=CC=C23)=O)([H])[C@@H](C)CC)=O)CC4=CC=C(C=C4)Cl)N[C@H]1CC5=CNC6=CC=CC=C56
Biological Activity: KRL74 is a cyclic peptide inhibitor for interaction between the p6 domain of the HIV Gag protein and the UEV domain of the human TSG101 protein(p6/UEV) with an IC50 of 5.44 μM and a Kd of 11.9 μM. KRL74 inhibits the budding process of HIV from host cells with an IC50 of 2 μM in virus-like particle (VLP) budding assay[1].
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KRL74 | KRL74 is a cyclic peptide inhibitor for interaction between the p6 domain of the HIV Gag protein and the UEV domain of the human TSG101 protein(p6/UEV) with an IC50 of 5.44 μM and a Kd of 11.9 μM. KRL74 inhibits the budding process of HIV from host cells with an IC50 of 2 μM in virus-like particle (VLP) budding assay. | |||||||||||||||||||||
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