2436472-47-6
Chemical Structure
ARN-75039
- CAS No.: 2436472-47-6
- Formula:C27H30N2O2
- Molecular Weight:414.54
InChIKey: TWUXCBSMDFLDBC-UHFFFAOYSA-N
SMILES: CC1=CC2=NC=C(N2C=C1C3=CC=C(C=C3)OC(C)C)C4=CC=C(C=C4)OC(C)(C)C
Biological Activity: ARN-75039 is an orally active arenavirus inhibitor. ARN-75039 binds to sites on the GP2 subunit of the mammarenavirus glycoprotein complex, stabilizes prefusion conformation, and blocks viral entry and endosomal membrane fusion to inhibit viral replication and spread. ARN-75039 can be used for the research of lassa fever, arenaviral hemorrhagic fever, and lethal Junín virus infection[1][2][3].
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ARN-75039 | ARN-75039 is an orally active arenavirus inhibitor. ARN-75039 binds to sites on the GP2 subunit of the mammarenavirus glycoprotein complex, stabilizes prefusion conformation, and blocks viral entry and endosomal membrane fusion to inhibit viral replication and spread. ARN-75039 can be used for the research of lassa fever, arenaviral hemorrhagic fever, and lethal Junín virus infection. | |||||||||||||||||||||
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- [1]. Eudy E, et al. The virus entry inhibitor ARN-75039 provides therapeutic protection against Lassa virus infection in guinea pigs. Sci Transl Med. 2026;18(845):eadx0938. [Content Brief]
- [2]. Gowen BB, et al. Potent inhibition of arenavirus infection by a novel fusion inhibitor. Antiviral Res. 2021 Sep;193:105125. [Content Brief]
- [3]. Westover JB, et al. Coadministration of LHF-535 and favipiravir protects against experimental Junín virus infection and disease. Antiviral Res. 2024;229:105952. [Content Brief]
Keywords
