244148-46-7
244148-46-7
Chemical Structure
Isogranulatimide
- CAS No.: 244148-46-7
- Formula:C15H8N4O2
- Molecular Weight:276.25
IUPAC Name: imidazo[1',2':1,6]pyrrolo[3',4':4,5]pyrido[2,3-b]indole-1,3(2H,8H)-dione
InChIKey: HKUUUAMEDKSFAG-UHFFFAOYSA-N
SMILES: O=C(C1=C2C3=NC=CN3C(N4)=C1C5=C4C=CC=C5)NC2=O
Biological Activity: Isogranulatimide is a selective checkpoint kinase 1 (Chk1) inhibitor with an IC50 value of 0.1 μM. Isogranulatimide inhibits the G2/M checkpoint and inhibits the growth of p53-mutant tumor cells. Isogranulatimide is promising for research of tumors associated with DNA damage response[1][2].
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Isogranulatimide | Isogranulatimide is a selective checkpoint kinase 1 (Chk1) inhibitor with an IC50 value of 0.1 μM. Isogranulatimide inhibits the G2/M checkpoint and inhibits the growth of p53-mutant tumor cells. Isogranulatimide is promising for research of tumors associated with DNA damage response. | |||||||||||||||||||||
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References
- [1]. Jiang X, et al. Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide. Mol Cancer Ther. 2004 Oct;3(10):1221-7. [Content Brief]
- [2]. Lavrard H, et al. Synthesis and in vitro antiproliferative activity of amido and amino analogues of the marine alkaloid isogranulatimide. ChemMedChem. 2015 Apr;10(4):607-9. [Content Brief]
