Isogranulatimide
Isogranulatimide is a selective checkpoint kinase 1 (Chk1) inhibitor with an IC50 value of 0.1 μM. Isogranulatimide inhibits the G2/M checkpoint and inhibits the growth of p53-mutant tumor cells. Isogranulatimide is promising for research of tumors associated with DNA damage response.
For research use only. We do not sell to patients.
- CAS No.: 244148-46-7
- Formula: C15H8N4O2
- Molecular Weight:276.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Chk1 0.1 μM (IC50) |
Chemical Information
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CAS No. 244148-46-7
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Molecular Weight 276.25
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Formula C15H8N4O2
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SMILES
O=C(C1=C2C3=NC=CN3C(N4)=C1C5=C4C=CC=C5)NC2=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Jiang X, et al. Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide. Mol Cancer Ther. 2004 Oct;3(10):1221-7. [Content Brief]
[2]. Lavrard H, et al. Synthesis and in vitro antiproliferative activity of amido and amino analogues of the marine alkaloid isogranulatimide. ChemMedChem. 2015 Apr;10(4):607-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Isogranulatimide Related Classifications
HY-112347 Related Classifications
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