2. Cell Cycle/DNA Damage
  3. Checkpoint Kinase (Chk)
  4. Isogranulatimide

Isogranulatimide is a selective checkpoint kinase 1 (Chk1) inhibitor with an IC50 value of 0.1 μM. Isogranulatimide inhibits the G2/M checkpoint and inhibits the growth of p53-mutant tumor cells. Isogranulatimide is promising for research of tumors associated with DNA damage response.

For research use only. We do not sell to patients.

Isogranulatimide

Isogranulatimide Chemical Structure

CAS No. : 244148-46-7

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Isogranulatimide Related Antibodies

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Description

Isogranulatimide is a selective checkpoint kinase 1 (Chk1) inhibitor with an IC50 value of 0.1 μM. Isogranulatimide inhibits the G2/M checkpoint and inhibits the growth of p53-mutant tumor cells. Isogranulatimide is promising for research of tumors associated with DNA damage response[1][2].

IC50 & Target

Chk1

0.1 μM (IC50)

Molecular Weight

276.25

Formula

C15H8N4O2
CAS No.
SMILES

O=C(C1=C2C3=NC=CN3C(N4)=C1C5=C4C=CC=C5)NC2=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Isogranulatimide Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isogranulatimide244148-46-7Checkpoint Kinase (Chk)Inhibitorinhibitorinhibit

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