244160-11-0
244160-11-0
Chemical Structure
K185
- CAS. Nr.: 244160-11-0
- Formula:C24H28N2O2
- Molecular Weight:376.49
InChIKey: SPIFQXPRSJKRAO-UHFFFAOYSA-N
SMILES: O=C(CCC)NCCC1=C(C2=CC=CC=C2CCC3)N3C4=C1C=C(C=C4)OC
Biological Activity: K185 is a selective MT2 melatonin receptor antagonist. K185 has a pKi of 9.30 for human MT2. K185 can be used for research on febrile seizures[1][2][3][4].
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K185 | K185 is a selective MT2 melatonin receptor antagonist. K185 has a pKi of 9.30 for human MT2. K185 can be used for research on febrile seizures. | |||||||||||||||||||||
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References
- [1]. Sugden D, et al. Design of subtype selective melatonin receptor agonists and antagonists. Reproduction, nutrition, development. 1999;39(3):335-44.
- [2]. Ramsay S, et al. Melatonin inhibits muscular-mucosal stretch-sensitive bladder afferents via the MT2 receptors. Scientific reports. 2022 Oct 21;12(1):17686. [Content Brief]
- [3]. Mubashshir MD, et al. Analyzing the responses of saccharin in context with melatonin receptors on the melanophores of the fish Labeo rohita (Ham.). Journal of receptor and signal transduction research. 2012 Apr;32(2):114-9.
- [4]. Mogulkoc R, et al. Role of Melatonin Receptors in Hyperthermia-Induced Acute Seizure Model of Rats. Journal of molecular neuroscience : MN. 2019 Dec;69(4):636-642.
