2454045-15-7
Chemical Structure
Biotin-cholesterol
- CAS No.: 2454045-15-7
- Formula:C37H60N2O3S
- Molecular Weight:612.95
InChIKey: VMAHKODQCCBRNG-VXVZIODVSA-N
SMILES: C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OC(CCCC[C@H]4[C@]5([H])[C@](NC(N5)=O)([H])CS4)=O)([H])[C@@]6([H])[C@](CC3)([C@@](CC6)([H])[C@H](C)CCCC(C)C)C
Biological Activity: Biotin-cholesterol is a biotinylated form of Cholesterol (HY-N0322). Biotin-cholesterol is a liver-targeting ligand (linking cholesterol and biotin via a Gly-Lys dipeptide linker), as well as an enhancer of the component activity of streptavidin-mediated siRNA nanocomplexes. Biotin-cholesterol promotes receptor-mediated endocytosis of the relevant siRNA nanocomplexes, protects siRNA from serum degradation, enables efficient siRNA delivery, and drives target gene silencing. Biotin-cholesterol shows no cytotoxicity in hepatic stellate cells. Biotin-cholesterol can be used in the research of alcoholic liver fibrosis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Biotin-cholesterol | 97.2% | Biotin-cholesterol is a biotinylated form of Cholesterol (HY-N0322). Biotin-cholesterol is a liver-targeting ligand (linking cholesterol and biotin via a Gly-Lys dipeptide linker), as well as an enhancer of the component activity of streptavidin-mediated siRNA nanocomplexes. Biotin-cholesterol promotes receptor-mediated endocytosis of the relevant siRNA nanocomplexes, protects siRNA from serum degradation, enables efficient siRNA delivery, and drives target gene silencing. Biotin-cholesterol shows no cytotoxicity in hepatic stellate cells. Biotin-cholesterol can be used in the research of alcoholic liver fibrosis. | ||||||||||||||||||||
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