245744-13-2

RWJ52353 hydrochloride Chemical Structure
245744-13-2

Chemical Structure

RWJ52353 hydrochloride

  • CAS No.: 245744-13-2
  • Formula:C11H11ClN2S
  • Molecular Weight:238.74

IUPAC Name: 5-(6,7-dihydrobenzo[b]thiophen-4-yl)-1H-imidazole hydrochloride

InChIKey: LIHWQUZNTRDJFW-UHFFFAOYSA-N

SMILES: C1(C2=CCCC3=C2C=CS3)=CN=CN1.Cl

Biological Activity: RWJ-52353 hydrochloride is an orally potent, highly selective α2D adrenergic receptor agonist (Ki: 1.5 nM) with potential analgesic effects. RWJ-52353 hydrochloride demonstrated analgesic activity in abdominal tests in rats and mice, and improved agitation in mice in the hot plate test and tail flick test. RWJ-52353 hydrochloride also regulates the organic cation transporter (OCT) subtype, inhibiting rOCT1 and rOCT2 with IC50s of 100 μM and 20 μM respectively; it also activates rOCT3, affecting [3H]-1- in cells. Methyl-4-phenylpyridinium ([3H]MPP) transport[1][2].

Cat. No. Product Name Purity Description Pricing
HY-103216A 		RWJ52353 hydrochloride RWJ-52353 hydrochloride is an orally potent, highly selective α2D adrenergic receptor agonist (Ki: 1.5 nM) with potential analgesic effects. RWJ-52353 hydrochloride demonstrated analgesic activity in abdominal tests in rats and mice, and improved agitation in mice in the hot plate test and tail flick test. RWJ-52353 hydrochloride also regulates the organic cation transporter (OCT) subtype, inhibiting rOCT1 and rOCT2 with IC50s of 100 μM and 20 μM respectively; it also activates rOCT3, affecting [3H]-1- in cells. Methyl-4-phenylpyridinium ([3H]MPP) transport.
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