247257-48-3
Chemical Structure
Fimasartan
Synonym(s): BR-A-657
- CAS No.: 247257-48-3
- Formula:C27H31N7OS
- Molecular Weight:501.65
IUPAC Name: 2-(1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-N,N-dimethylethanethioamide
InChIKey: AMEROGPZOLAFBN-UHFFFAOYSA-N
SMILES: O=C1N(C(CCCC)=NC(C)=C1CC(N(C)C)=S)CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2
Biological Activity: Fimasartan (BRA-657) is an orally effective angiotensin receptor AT1 non-peptide antagonist. Fimasartan has antihypertensive effects. Fimasartan improves neuroinflammation and brain injury mediated by NLRP3 inflammatome after intracerebral hemorrhage, and has neuroprotective effect. Fimasartan inhibits the expression of inducible nitric oxide synthase through the inactivation of NF-κB and activator protein-1[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Fimasartan | 99.60% | Fimasartan (BRA-657) is an orally effective angiotensin receptor AT1 non-peptide antagonist. Fimasartan has antihypertensive effects. Fimasartan improves neuroinflammation and brain injury mediated by NLRP3 inflammatome after intracerebral hemorrhage, and has neuroprotective effect. Fimasartan inhibits the expression of inducible nitric oxide synthase through the inactivation of NF-κB and activator protein-1. | ||||||||||||||||||||
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Fimasartan-d6 | Fimasartan-d6 is deuterium labeled Fimasartan. | |||||||||||||||||||||
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Similarity Score 0.67
HY-Z8483Losartan impurity 16 -
Similarity Score 0.67
HY-Z7663Losartan impurity 8 -
Similarity Score 0.67
HY-114950EXP3179 -
Similarity Score 0.66
HY-103247EMD 66684 -
Similarity Score 0.65
HY-117858CL-329167 -
Similarity Score 0.65
HY-123974BR101549 -
Similarity Score 0.65
HY-W724743Losartan azide -
Similarity Score 0.65
HY-180401DMP 811 -
Similarity Score 0.64
HY-17512S3Losartan-d2 -
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References
- [1]. Ryu S, et al. Fimasartan, anti-hypertension drug, suppressed inducible nitric oxide synthase expressions via nuclear factor-kappa B and activator protein-1 inactivation. Biol Pharm Bull. 2013;36(3):467-74. [Content Brief]
- [2]. Yang X, Sun J, Kim TJ, Kim YJ, Ko SB, Kim CK, Jia X, Yoon BW. Pretreatment with low-dose fimasartan ameliorates NLRP3 inflammasome-mediated neuroinflammation and brain injury after intracerebral hemorrhage. Exp Neurol. 2018 Dec;310:22-32. [Content Brief]
- [3]. Chi YH, et al. Pharmacological characterization of BR-A-657, a highly potent nonpeptide angiotensin II receptor antagonist. Biol Pharm Bull. 2013;36(7):1208-15. [Content Brief]
