2490699-40-4
2490699-40-4
Chemical Structure
LDHA/PDKs-IN-1
- CAS No.: 2490699-40-4
- Formula:C19H21FN2O4
- Molecular Weight:360.38
IUPAC Name: 3-(2-(4-(4-fluorobenzoyl)piperazin-1-yl)ethoxy)-2-methyl-4H-pyran-4-one
InChIKey: AHYWOCBRZPCRAD-UHFFFAOYSA-N
SMILES: CC1=C(C(C=CO1)=O)OCCN2CCN(CC2)C(C3=CC=C(C=C3)F)=O
Biological Activity: LDHA/PDKs-IN-1 (compound 20e) is a potent and dual inhibitor of PDKs and LDHA with IC50s of 0.8 and 0.15 μM, respectively. LDHA/PDKs-IN-1 reduces A549 cell proliferation with an EC50 of 13.2 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-1 has the potential for the research of cancer diseases[1].
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LDHA/PDKs-IN-1 | LDHA/PDKs-IN-1 (compound 20e) is a potent and dual inhibitor of PDKs and LDHA with IC50s of 0.8 and 0.15 μM, respectively. LDHA/PDKs-IN-1 reduces A549 cell proliferation with an EC50 of 13.2 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-1 has the potential for the research of cancer diseases. | |||||||||||||||||||||
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