2490699-44-8
Chemical Structure
LDHA/PDKs-IN-2
- CAS No.: 2490699-44-8
- Formula:C17H20N2O5
- Molecular Weight:332.35
IUPAC Name: 3-(2-(4-(furan-2-carbonyl)piperazin-1-yl)ethoxy)-2-methyl-4H-pyran-4-one
InChIKey: ZPAXPXPEMPOWGE-UHFFFAOYSA-N
SMILES: CC1=C(C(C=CO1)=O)OCCN2CCN(CC2)C(C3=CC=CO3)=O
Biological Activity: LDHA/PDKs-IN-2 (compound 20k) is a potent and dual inhibitor of PDKs and LDHA with IC50s of 1.6 and 0.7 μM, respectively. LDHA/PDKs-IN-2 reduces A549 cell proliferation with an EC50 of 15.7 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-2 has the potential for the research of cancer diseases[1].
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LDHA/PDKs-IN-2 | LDHA/PDKs-IN-2 (compound 20k) is a potent and dual inhibitor of PDKs and LDHA with IC50s of 1.6 and 0.7 μM, respectively. LDHA/PDKs-IN-2 reduces A549 cell proliferation with an EC50 of 15.7 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-2 has the potential for the research of cancer diseases. | |||||||||||||||||||||
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Keywords
