2516232-89-4
2516232-89-4
Chemical Structure
URAT1-IN-14
- CAS No.: 2516232-89-4
- Formula:C19H19NO3S
- Molecular Weight:341.42
SMILES: O=C(C1(SC2=CC=CC=C2N3CCOC4=CC=CC=C34)CCC1)O
Biological Activity: URAT1-IN-14 is a potent and orally active Urate transporter 1 (URAT1) inhibitor. URAT1-IN-14 inhibits the human URAT1 in HEK293 cells with an IC50 of 0.72 μM. URAT1-IN-14 exhibits low cytotoxic in Hep-G2 cells. URAT1-IN-14 shows urate-lowering effect in hyperuricemia mouse models. URAT1-IN-14 can be used for the study of hyperuricemia and gout[1].
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URAT1-IN-14 | URAT1-IN-14 is a potent and orally active Urate transporter 1 (URAT1) inhibitor. URAT1-IN-14 inhibits the human URAT1 in HEK293 cells with an IC50 of 0.72 μM. URAT1-IN-14 exhibits low cytotoxic in Hep-G2 cells. URAT1-IN-14 shows urate-lowering effect in hyperuricemia mouse models. URAT1-IN-14 can be used for the study of hyperuricemia and gout. | |||||||||||||||||||||
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