2529657-32-5
Chemical Structure
Anticancer agent 63
- CAS No.: 2529657-32-5
- Formula:C17H24F3NOSe
- Molecular Weight:394.33
IUPAC Name: 2-(4-isobutylphenyl)-N-(3-((trifluoromethyl)selanyl)propyl)propanamide
InChIKey: YQWAFTSNGPUFSE-UHFFFAOYSA-N
SMILES: CC(CC1=CC=C(C=C1)C(C(NCCC[Se]C(F)(F)F)=O)C)C
Biological Activity: Anticancer agent 63 (compound 3h) shows active in reducing the viability of different cancer cell lines, including SW480, HeLa, A549 and MCF-7, with IC50 values at 24 h of 4.9, 11.5, 9.4, and 3.4 μM, respectively. Anticancer agent 63 induce apoptosis in MCF-7 cells via down-regulating the expression of Bcl-2 and up-regulating the expression of IL-2 and Caspase-3. Anticancer agent 63 also shows antioxidant activity[1].
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Anticancer agent 63 | Anticancer agent 63 (compound 3h) shows active in reducing the viability of different cancer cell lines, including SW480, HeLa, A549 and MCF-7, with IC50 values at 24 h of 4.9, 11.5, 9.4, and 3.4 μM, respectively. Anticancer agent 63 induce apoptosis in MCF-7 cells via down-regulating the expression of Bcl-2 and up-regulating the expression of IL-2 and Caspase-3. Anticancer agent 63 also shows antioxidant activity. | |||||||||||||||||||||
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Keywords
