2548763-07-9
Chemical Structure
DRhFe
- CAS No.: 2548763-07-9
- Formula:C46H56N6O5S
- Molecular Weight:805.04
InChIKey: MOXSENZKWBWMHK-UHFFFAOYSA-N
SMILES: CCN(C1=CC=C2C(OC3=C(C24C5=C(C(N4CCN(CCNS(=O)(C6=C7C=CC=C(C7=CC=C6)N(C)C)=O)CCO)=O)C=CC=C5)C=CC(N(CC)CC)=C3)=C1)CC
Biological Activity: DRhFe is a reversible ratiometric FRET fluorescent probe for the specific detection of Fe3+. DRhFe detects fluctuations in Fe3+ concentration during cellular ferroptosis. DRhFe chelates Fe3+ via the HEDTA group to induce spirolactam ring opening, which in turn activates the intramolecular FRET effect, thereby enabling ratiometric fluorescence detection of Fe3+ (Ex/Em = 405 nm/483 nm (free form); Ex/Em = 543/576 nm (Fe3+-bound form))[1][2].
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DRhFe | DRhFe is a reversible ratiometric FRET fluorescent probe for the specific detection of Fe3+. DRhFe detects fluctuations in Fe3+ concentration during cellular ferroptosis. DRhFe chelates Fe3+ via the HEDTA group to induce spirolactam ring opening, which in turn activates the intramolecular FRET effect, thereby enabling ratiometric fluorescence detection of Fe3+ (Ex/Em = 405 nm/483 nm (free form); Ex/Em = 543/576 nm (Fe3+-bound form)). | |||||||||||||||||||||
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References
- [1]. Gao J, et al. Reversible FRET Fluorescent Probe for Ratiometric Tracking of Endogenous Fe in Ferroptosis. Inorganic chemistry. 2020 Aug 03;59(15):10920-10927.
- [2]. Mårdh G, et al. Human class I alcohol dehydrogenases catalyze the interconversion of alcohols and aldehydes in the metabolism of dopamine. Biochemistry. 1986 Nov 18;25(23):7279-82.
