255713-53-2
255713-53-2
Chemical Structure
A-123189
- CAS No.: 255713-53-2
- Formula:C26H28N4O3S
- Molecular Weight:476.59
IUPAC Name: 3-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-5-(m-tolyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
InChIKey: PANBMHHKBRMYAL-UHFFFAOYSA-N
SMILES: O=C1N(C(C2=C(N1)SC=C2C3=CC=CC(C)=C3)=O)CCN4CCN(CC4)C5=CC=CC=C5OC
Biological Activity: A-123189 is a selective and potent α1D antagonist with Kis of 0.312 and 0.17 for human α1D and rat α1D, respectively. A-123189 displays selectivities between 10- to 20-fold for the α1D receptor over the human α1A and rat α1A receptors[1].
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A-123189 | A-123189 is a selective and potent α1D antagonist with Kis of 0.312 and 0.17 for human α1D and rat α1D, respectively. A-123189 displays selectivities between 10- to 20-fold for the α1D receptor over the human α1A and rat α1A receptors. | |||||||||||||||||||||
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References
Keywords
