2561414-56-8
Chemical Structure
GNF2133
- CAS No.: 2561414-56-8
- Formula:C24H30N6O2
- Molecular Weight:434.53
IUPAC Name: 4-ethyl-N-(4-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)pyridin-2-yl)piperazine-1-carboxamide
InChIKey: SAZIAQSVBIWIDU-UHFFFAOYSA-N
SMILES: CCN1CCN(CC1)C(NC2=NC=CC(C3=CN(C4=CN=CC=C34)C5CCOCC5)=C2)=O
Biological Activity: GNF2133 is a potent, selective and orally active DYRK1A inhibitor with IC50s of 0.0062, >50 µM for DYRK1A and GSK3β, respectively. GNF2133 shows good proliferation potency and efficacy on rat and human primary β-cell. GNF2133 significantly improves glucose disposal capacity and increases insulin secretion. GNF2133 has the potential for the research of type 1 diabetes[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GNF2133 | 99.67% | GNF2133 is a potent, selective and orally active DYRK1A inhibitor with IC50s of 0.0062, >50 µM for DYRK1A and GSK3β, respectively. GNF2133 shows good proliferation potency and efficacy on rat and human primary β-cell. GNF2133 significantly improves glucose disposal capacity and increases insulin secretion. GNF2133 has the potential for the research of type 1 diabetes. | ||||||||||||||||||||
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Keywords
