2566710-63-0
2566710-63-0
Chemical Structure
PD1-PDL1-IN 2
- CAS No.: 2566710-63-0
- Formula:C37H41ClN4O7S
- Molecular Weight:721.26
InChIKey: QJSJWFVBDAPNAE-UHFFFAOYSA-N
SMILES: N#CC1=CN=CC(COC2=CC(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)=C(C=C2CN(CCS(=O)(O)=O)CCCN(C)C)Cl)=C1
Biological Activity: PD1-PDL1-IN 2 (ZE132) is a potent and selective PD-1/PD-L1 inhibitor, which has robust anti-tumour activity in vivo. PD1-PDL1-IN 2 promotes cytotoxic T-cell tumour infiltration and induces IL-2 expression. In addition, PD1-PDL1-IN 2 elicits strong inhibitory effects on the mRNA expression of TGF-β[1].
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PD1-PDL1-IN 2 | PD1-PDL1-IN 2 (ZE132) is a potent and selective PD-1/PD-L1 inhibitor, which has robust anti-tumour activity in vivo. PD1-PDL1-IN 2 promotes cytotoxic T-cell tumour infiltration and induces IL-2 expression. In addition, PD1-PDL1-IN 2 elicits strong inhibitory effects on the mRNA expression of TGF-β. | |||||||||||||||||||||
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References
Keywords
