2566733-45-5

HLB-0532259 Chemical Structure
2566733-45-5

Chemical Structure

HLB-0532259

  • CAS No.: 2566733-45-5
  • Formula:C40H44N8O7
  • Molecular Weight:748.83

InChIKey: AGMODSYVRUVEOY-UHFFFAOYSA-N

SMILES: O=C(N(C)C)C(N1C2CCCC2)=CC3=C1N=C(NC4=CC=C(C(NCCCCCCOC5=C(C(N(C6CCC(NC6=O)=O)C7=O)=O)C7=CC=C5)=O)C=C4)N=C3

Biological Activity: HLB-0532259 is a PROTAC degrader for Aurora-A and N-Myc. HLB-0532259 degrades Aurora-Ain a non-MYCN amplified MCF-7 with a DC50 of 20.2 nM, degrades N-Myc in MYCN amplified cells SK-N-BE and Kelly with DC50 of 179 nM and 229 nM. HLB-0532259 exhibits antitumor efficacy in mouse models[1].

Cat. No. Product Name Purity Description Pricing
HY-168439 		HLB-0532259 98.30% HLB-0532259 is a PROTAC degrader for Aurora-A and N-Myc. HLB-0532259 degrades Aurora-Ain a non-MYCN amplified MCF-7 with a DC50 of 20.2 nM, degrades N-Myc in MYCN amplified cells SK-N-BE and Kelly with DC50 of 179 nM and 229 nM. HLB-0532259 exhibits antitumor efficacy in mouse models.
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