2581277-82-7
2581277-82-7
Chemical Structure
MMV022224
- CAS. Nr.: 2581277-82-7
- Formula:C25H28N4
- Molecular Weight:384.52
InChIKey: OJQSBLNKBHUISS-UHFFFAOYSA-N
SMILES: CN(C)CC1=CC=C(C2=CC3=C(C4=CC=C(CN(C)C)C=C4)C=CN=C3N2)C=C1
Biological Activity: MMV022224 is an antimalarial agent that acts by selectively binding to and inhibiting the enzymatic activity of PfPK6. MMV022224 disrupts hemoglobin catabolism, induces peptide accumulation, and targets the ring and trophozoite stages of Plasmodium falciparum. MMV022224 can be used in malaria-related research[1][2].
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MMV022224 | MMV022224 is an antimalarial agent that acts by selectively binding to and inhibiting the enzymatic activity of PfPK6. MMV022224 disrupts hemoglobin catabolism, induces peptide accumulation, and targets the ring and trophozoite stages of Plasmodium falciparum. MMV022224 can be used in malaria-related research. | |||||||||||||||||||||
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References
- [1]. Syed AJ, et al. Using Unbiased Chemical Proteomics Approaches to Explore the Target Landscape of the Resistance Refractory 7-Azaindole MMV022224 in Plasmodium falciparum. ACS Infect Dis. 2026 Jun 25. [Content Brief]
- [2]. Murithi JM, et al. Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery. Cell chemical biology. 2020 Feb 20;27(2):158-171.e3. [Content Brief]
Keywords
