2597186-19-9
Chemical Structure
SR-0813
- CAS No.: 2597186-19-9
- Formula:C25H32N6O3S
- Molecular Weight:496.62
IUPAC Name: N-cyclobutyl-2-(3-((N-(2-(piperidin-1-yl)ethyl)sulfamoyl)amino)phenyl)imidazo[1,2-a]pyridine-6-carboxamide
InChIKey: GPMTWAPXRJMXCC-UHFFFAOYSA-N
SMILES: O=C(C1=CN2C=C(C3=CC(NS(=O)(NCCN4CCCCC4)=O)=CC=C3)N=C2C=C1)NC5CCC5
Biological Activity: SR-0813 is a potent and selective ENL/AF9 YEATS domain inhibitor. SR-0813 has IC50 and EC50 values of 25 nM and 205 nM for ENL YEATS domain, respectively. SR-0813 has IC50 and EC50 values of 311 nM and 76 nM (CETSA) for AF9 YEATS domain, respectively. SR-0813 binds MAP3K19 with over 100-fold lower affinity (Kd=3.5 μM) than ENL YEATS (Kd=30 nM). SR-0813 can be used for the research of acute leukemia[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SR-0813 | 99.93% | SR-0813 is a potent and selective ENL/AF9 YEATS domain inhibitor. SR-0813 has IC50 and EC50 values of 25 nM and 205 nM for ENL YEATS domain, respectively. SR-0813 has IC50 and EC50 values of 311 nM and 76 nM (CETSA) for AF9 YEATS domain, respectively. SR-0813 binds MAP3K19 with over 100-fold lower affinity (Kd=3.5 μM) than ENL YEATS (Kd=30 nM). SR-0813 can be used for the research of acute leukemia. | ||||||||||||||||||||
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Keywords
