2597345-07-6
2597345-07-6
Chemical Structure
UR241-2
- CAS No.: 2597345-07-6
- Formula:C20H22N6O2
- Molecular Weight:378.43
InChIKey: PLPQYRICJPQFMT-UHFFFAOYSA-N
SMILES: COC1=CC(N2CCNCC2)=CC=C1NC(C3=CC=CC(C4=NNC=C4)=N3)=O
Biological Activity: UR241-2 is an IRAK4 inhibitor. UR241-2 suppresses IL-1–induced IRAK1/4 signaling, NF-κβ activation, and phosphorylation of p65 and p38. UR241-2 selectively inhibits leukemia stem cell clonogenicity. UR241-2 can serve as a ligand for target proteins for PROTAC, facilitating the development and design of PROTAC degraders for IRAK4. UR241-2 can be used in the research of acute myeloid leukemia[1].
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UR241-2 | 99.68% | UR241-2 is an IRAK4 inhibitor. UR241-2 suppresses IL-1–induced IRAK1/4 signaling, NF-κβ activation, and phosphorylation of p65 and p38. UR241-2 selectively inhibits leukemia stem cell clonogenicity. UR241-2 can serve as a ligand for target proteins for PROTAC, facilitating the development and design of PROTAC degraders for IRAK4. UR241-2 can be used in the research of acute myeloid leukemia. | ||||||||||||||||||||
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