26198-65-2
Chemical Structure
Aerobactin
- CAS No.: 26198-65-2
- Formula:C22H36N4O13
- Molecular Weight:564.54
IUPAC Name: (8S,16S)-3,12,21-trihydroxy-2,10,14,22-tetraoxo-3,9,15,21-tetraazatricosane-8,12,16-tricarboxylic acid
InChIKey: KDHHWXGBNUCREU-HOTGVXAUSA-N
SMILES: CC(N(CCCC[C@H](NC(CC(O)(CC(N[C@@H](CCCCN(C(C)=O)O)C(O)=O)=O)C(O)=O)=O)C(O)=O)O)=O
Biological Activity: Aerobactin is a siderophore produced by bacteria. Aerobactin exhibits the primary activity of chelating ferric ions and transporting them into bacterial cells. Aerobactin promotes bacterial growth, biofilm formation, antioxidant stress resistance, and enhances bacterial virulence and transcellular translocation ability under iron-deficient conditions. Aerobactin is used in research on bacterial infections[1][2][3][4][5].
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Aerobactin | 97.23% | Aerobactin is a siderophore produced by bacteria. Aerobactin exhibits the primary activity of chelating ferric ions and transporting them into bacterial cells. Aerobactin promotes bacterial growth, biofilm formation, antioxidant stress resistance, and enhances bacterial virulence and transcellular translocation ability under iron-deficient conditions. Aerobactin is used in research on bacterial infections. | ||||||||||||||||||||
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Aerobactin (Standard) | ≥98% | Calcium gluconate (Standard) is the analytical standard of Calcium gluconate. This product is intended for research and analytical applications. Calcium Gluconate Monohydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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References
- [1]. Hernandez GE, et al. Aerobactin is a key driver of hypervirulent Klebsiella pneumoniae translocation and virulence. PLoS pathogens. 2026 Apr;22(4):e1014122.
- [2]. LI C, et al. Aerobactin-mediated iron acquisition enhances biofilm formation, oxidative stress resistance, and virulence of Yersinia pseudotuberculosis. Frontiers in Microbiology, 2021, 12: 699913.
- [3]. Bailey DC, et al. Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae. J Biol Chem. 2018 May 18;293(20):7841-7852.
- [4]. Lawlor KM, et al. Aerobactin genes in Shigella spp. Journal of bacteriology. 1984 Oct;160(1):266-72. [Content Brief]
- [5]. LAWLOR K M, et al. Aerobactin genes in Shigella spp. . Journal of Bacteriology, 1984, 160(1): 266-272.
