2639392-70-2
2639392-70-2
Chemical Structure
Mefluleucine hydrochloride
Synonym(s): NV-5138 hydrochloride
- CAS No.: 2639392-70-2
- Formula:C7H14ClF2NO2
- Molecular Weight:217.64
IUPAC Name: (S)-2-amino-5,5-difluoro-4,4-dimethylpentanoic acid hydrochloride
InChIKey: SIUFCONWYBJSOP-WCCKRBBISA-N
SMILES: N[C@@H](CC(C)(C(F)F)C)C(O)=O.Cl
Biological Activity: Mefluleucine (NV-513) hydrochloride, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. Mefluleucine hydrochloride is used for antidepressant studies[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Mefluleucine hydrochloride | 98.0% | Mefluleucine (NV-513) hydrochloride, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. Mefluleucine hydrochloride is used for antidepressant studies. | ||||||||||||||||||||
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References
- [1]. Sengupta S, et al. Discovery of NV-5138, the first selective Brain mTORC1 activator. Sci Rep. 2019 Mar 11;9(1):4107. [Content Brief]
- [2]. Kato T, et al. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J Clin Invest. 2019 Apr 16;129(6):2542-2554. [Content Brief]
