2640723-72-2
Chemical Structure
WB214
- CAS No.: 2640723-72-2
- Formula:C44H43ClF3N5O7
- Molecular Weight:846.29
InChIKey: WGGGBWUFPMJXRU-UHFFFAOYSA-N
SMILES: O=C(C1=C(C(N(CC2=CC(F)=C(C(F)=C2)F)C(CCCCC#CC3=CC=CC4=C3CN(C5C(NC(CC5)=O)=O)C4=O)=O)C(NC(C)(C)C)=O)C6=C(C=C(C=C6)Cl)N1)OCC
Biological Activity: WB214 is an MDM2 and GSPT1 degrader with human MDM2 Ki >10 μM. WB214 induces a neo-interaction between MDM2 and the cereblon E3 ligase complex, triggering MDM2 ubiquitination, proteasomal degradation, and bystander p53 degradation, and does not bind MDM2’s p53 binding region. WB214 induces GSPT1 degradation, and exhibits anti-proliferative activity in leukemia cells. WB214 can be used for the research of leukemia[1].
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WB214 | WB214 is an MDM2 and GSPT1 degrader with human MDM2 Ki >10 μM. WB214 induces a neo-interaction between MDM2 and the cereblon E3 ligase complex, triggering MDM2 ubiquitination, proteasomal degradation, and bystander p53 degradation, and does not bind MDM2’s p53 binding region. WB214 induces GSPT1 degradation, and exhibits anti-proliferative activity in leukemia cells. WB214 can be used for the research of leukemia. | |||||||||||||||||||||
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Keywords
