2645409-78-3
2645409-78-3
Chemical Structure
RMS-07
- CAS No.: 2645409-78-3
- Formula:C35H40N8O2
- Molecular Weight:604.74
IUPAC Name: 2-((2-acrylamido-4-(4-methylpiperazin-1-yl)phenyl)amino)-N-(2,6-diethylphenyl)-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide
InChIKey: QMTKZAHTDPRIFJ-UHFFFAOYSA-N
SMILES: O=C(C1=C2CCC3=CN=C(NC4=CC=C(N5CCN(C)CC5)C=C4NC(C=C)=O)N=C3N2C=C1)NC6=C(CC)C=CC=C6CC
Biological Activity: RMS-07 is a covalent Monopolar Spindle Kinase 1 (MPS1/TTK) inhibitor, with an apparent IC50 of 13.1 nM. RMS-07 targets a poorly conserved cysteine in the kinase's hinge region[1].
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RMS-07 | RMS-07 is a covalent Monopolar Spindle Kinase 1 (MPS1/TTK) inhibitor, with an apparent IC50 of 13.1 nM. RMS-07 targets a poorly conserved cysteine in the kinase's hinge region. | |||||||||||||||||||||
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References
Keywords
