265646-94-4
265646-94-4
Chemical Structure
NS3736
- CAS No.: 265646-94-4
- Formula:C15H9BrClF3N6O
- Molecular Weight:461.62
InChIKey: PTWUMGQRIORASC-UHFFFAOYSA-N
SMILES: O=C(NC1=C(C2=NN=NN2)C=C(Br)C=C1)NC3=CC=C(C(C(F)(F)F)=C3)Cl
Biological Activity: NS3736 is an orally effective chloride channel inhibitor that can be used for the research of osteoporosis. NS3736 targets the CIC-7 channel in osteocytes, blocks osteoclast acidification and resorption in vitro, with IC50=30 μM. In a rat model of ovariectomy-induced osteoporosis, NS3736 can enhance bone strength and bone density[1].
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NS3736 | NS3736 is an orally effective chloride channel inhibitor that can be used for the research of osteoporosis. NS3736 targets the CIC-7 channel in osteocytes, blocks osteoclast acidification and resorption in vitro, with IC50=30 μM. In a rat model of ovariectomy-induced osteoporosis, NS3736 can enhance bone strength and bone density. | |||||||||||||||||||||
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References
Keywords
