2669790-59-2
2669790-59-2
Chemical Structure
BCR-ABL-IN-4
- CAS No.: 2669790-59-2
- Formula:C27H24ClF2N5O4
- Molecular Weight:555.96
IUPAC Name: (R)-N-(4-(chlorodifluoromethoxy)phenyl)-5-(6-cyclopropyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)-6-(3-hydroxypyrrolidin-1-yl)nicotinamide
InChIKey: YKODBSQOEOUPRJ-LJQANCHMSA-N
SMILES: ClC(F)(F)OC(C=C1)=CC=C1NC(C2=CC(C3=CN=C(CN(C4CC4)C5=O)C5=C3)=C(N6C[C@@H](CC6)O)N=C2)=O
Biological Activity: BCR-ABL-IN-4 is a BCR-ABL inhibitor with anticancer effects. BCR-ABL-IN-4 inhibits the cancer cell growth with IC50 values of 0.67 nM and 16 nM for K562 cells and BCR-ABL T315I transfected Ba/F3 cells, respectively (WO2021143927A1; compound 11)[1].
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BCR-ABL-IN-4 | BCR-ABL-IN-4 is a BCR-ABL inhibitor with anticancer effects. BCR-ABL-IN-4 inhibits the cancer cell growth with IC50 values of 0.67 nM and 16 nM for K562 cells and BCR-ABL T315I transfected Ba/F3 cells, respectively (WO2021143927A1; compound 11). | |||||||||||||||||||||
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