2669844-82-8
Chemical Structure
BCPyr
- CAS No.: 2669844-82-8
- Formula:C58H65F2N11O8
- Molecular Weight:1082.20
IUPAC Name: (5-((((S)-2-((S)-3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)-3-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)methyl)pyrazin-2-yl)methyl (R)-3-(5-amino-4-carbamoyl-3-(4-(2,4-difluorophenoxy)phenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
InChIKey: PTEVOZUKHQQUNI-DLUJOBAXSA-N
SMILES: O=C(N1C[C@H](N2N=C(C3=CC=C(OC4=CC=C(F)C=C4F)C=C3)C(C(N)=O)=C2N)CCC1)OCC5=NC=C(COC6=CC7=C(C=C6)C[C@@H](C(N[C@@H]8CCCC9=C8C=CC=C9)=O)N(C([C@@H](NC([C@@H](NC)C)=O)C(C)(C)C)=O)C7)N=C5
Biological Activity: BCPyr is a PROTAC degrader targeting cIAP1 and BTK, with a Kd of 262 nM for human cIAP1, and Kd values of 262 nM and 692 nM for human BTK. BCPyr binds to the Bir3 domain of cIAP1, recruits BTK to cIAP1, and mediates the ubiquitination and degradation of BTK. BCPyr acts as a degrader, ternary complex stabilizer, cooperative binder, and higher-order assembly inducer. BCPyr can be used in studies related to leukemia and lymphoma[1].
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BCPyr | BCPyr is a PROTAC degrader targeting cIAP1 and BTK, with a Kd of 262 nM for human cIAP1, and Kd values of 262 nM and 692 nM for human BTK. BCPyr binds to the Bir3 domain of cIAP1, recruits BTK to cIAP1, and mediates the ubiquitination and degradation of BTK. BCPyr acts as a degrader, ternary complex stabilizer, cooperative binder, and higher-order assembly inducer. BCPyr can be used in studies related to leukemia and lymphoma. | |||||||||||||||||||||
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Keywords
