2691796-83-3
Chemical Structure
BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride
- CAS No.: 2691796-83-3
- Formula:C41H45Cl3N4O5
- Molecular Weight:780.18
IUPAC Name: 3-((4-chloro-5-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-((2-(piperazine-1-carbonyl)piperidin-1-yl)methyl)phenoxy)methyl)benzonitrile dihydrochloride
InChIKey: GHDAHXKKICFPOZ-UHFFFAOYSA-N
SMILES: N#CC1=CC=CC(COC2=CC(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)=C(C=C2CN6CCCCC6C(N7CCNCC7)=O)Cl)=C1.Cl.Cl
Biological Activity: BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1?(HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM[1].
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BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride | 95.01% | BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1?(HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. | ||||||||||||||||||||
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