2698320-33-9
2698320-33-9
Chemical Structure
UT-143
- CAS No.: 2698320-33-9
- Formula:C20H17F3N6O4
- Molecular Weight:462.38
InChIKey: PGSBKMRTKDTLSD-IBGZPJMESA-N
SMILES: N#CC(C=N1)=CN1C[C@@](OCC(C(OC)=O)=C)(C)C(NC2=CN=C(C#N)C(C(F)(F)F)=C2)=O
Biological Activity: UT-143 is an orally active, selective irreversible covalent antagonist of androgen receptor (AR). UT-143 inhibits the proliferation of AR-positive prostate cancer cells, reduces the weight of androgen target tissues in rats, and suppresses the growth of AR-positive xenograft tumors. UT-143 can be used for the research of prostate cancer[1].
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UT-143 | UT-143 is an orally active, selective irreversible covalent antagonist of androgen receptor (AR). UT-143 inhibits the proliferation of AR-positive prostate cancer cells, reduces the weight of androgen target tissues in rats, and suppresses the growth of AR-positive xenograft tumors. UT-143 can be used for the research of prostate cancer. | |||||||||||||||||||||
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References
Keywords
