27007-85-8
27007-85-8
Chemical Structure
Spiclomazine hydrochloride
Synonym(s): APY-606; Clospirazine hydrochloride
- CAS No.: 27007-85-8
- Formula:C22H25Cl2N3OS2
- Molecular Weight:482.49
IUPAC Name: 8-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-1-thia-4,8-diazaspiro[4.5]decan-3-one hydrochloride
InChIKey: JRSBQVOEILNXGS-UHFFFAOYSA-N
SMILES: O=C1CSC2(N1)CCN(CC2)CCCN3C4=C(SC5=CC=C(C=C35)Cl)C=CC=C4.[H]Cl
Biological Activity: Spiclomazine hydrochloride (APY-606) is an antipsychotic and antitumor agent. Spiclomazine hydrochloride inhibits KRas. Spiclomazine hydrochloride induces cancer cell apoptosis[1][2].
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Spiclomazine hydrochloride | Spiclomazine hydrochloride (APY-606) is an antipsychotic and antitumor agent. Spiclomazine hydrochloride inhibits KRas. Spiclomazine hydrochloride induces cancer cell apoptosis. | |||||||||||||||||||||
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References
- [1]. Zhao W, et al. Spiclomazine induces apoptosis associated with the suppression of cell viability, migration and invasion in pancreatic carcinoma cells. PLoS One. 2013 Jun 20;8(6):e66362. [Content Brief]
- [2]. Guo X, et al. Spiclomazine displays a preferential anti-tumor activity in mutant KRas-driven pancreatic cancer. Oncotarget. 2018 Jan 8;9(6):6938-6951. [Content Brief]
Keywords
